It's not an easy setting. There's A LOT of intricate lore to the game and it's setting, the PCs can be incredibly powerful and the system is a bit quirky... That said, it's a popular game but it's tough to run without the ability to herd cats or nail sand to the wall.
I really like the setting but the system...that's another matter entirely. Personally, I feel like it's a game that presents itself like it's supposed to be used in "sandbox style" play but really shouldn't be used that way. One of the major pieces of advice that I can give, if you want to run MtA, is to have a defined story you want to tell and have players willing to craft characters to fit that story otherwise it's going to be a zoo of misfit characters that can hobble gameplay more than enhance it. A good Session Zero where you and your players lay out your expectations and craft the Saga premise is really important.