Newbieness would be ok (and all three of you would need to be on board with trying it before I'd suggest it).
TOR's framework is it's own thing -- its fundamental mechanical die role is a d12+nd6 based on your skill in a thing. On the d6s an extra rune imparts either a great (1 6) or extraordinary (more than 1 6) success. In combat this means greater damage, out of combat it means greater overall success/impression.
In the case of TOR, your culture is fundamentally determinative in what your stats/skills are at start. Your profession/calling modifies them slightly but only slightly. There are no levels in TOR -- everything is through experience point gains through skill use.
I think there are a couple key differences:
1) some of the social interaction rules are more complicated - opinion varies on whether they're clunkier or more evocative of ME.
2) there's a "Hope" mechanic that is used to get bonuses or activate special skills. This is what Shadow points are measured against, so there's a much stronger focus in Hope vs. Shadow (versus AiME which puts Shadow against Wisdom for a smaller focus).
3) combat in TOR is more dangerous, as a rule and abstracted more than in AiME.
Other items like cultures, journeys, social encounters, fellowship phases, etc. are all in TOR and many of those concepts were adjusted and ported over to AiME, so your familiarity with them as concepts should map over to TOR easily if you collectively decide to give it a go.
Note, I've also asked the TOR folks if they'd like to come over here and do AiME.
In the end, if people aren't up for mixing, that's ok. =). Just making it an option since there's clearly a couple groups of people who like Tolkein afoot.