I have a general idea of an overarching plot for the first arc to involve most of the NPCs in one way or another. I'm building a potential scene list and working out how to best start.
I made a spreadsheet of the most linked people and places to try to see who and what appears to be of most interest to everyone. The list is sorted by links to people, then to places. Each entry is listed by number of links as follows:
Name: Total Links (Links to Leads / Links to NPCs / Links to Locations)
(for example, the first entry, Ms. Evelyn Parker has a total of 8 links, 3 to leads, 4 to other NPCs, and 1 to a location)
Ms. Evelyn Parker 8 (3/4/1)
Malachi 8 (3/3/2)
Elizabeth Cavendish 7 (3/3/1)
Connor Walsh 6 (5/1/0)
Amanda Smythe-Davies 6 (5/1/0)
Captain Kurk 5 (4/0/1)
Fiona McPhillips 5 (2/3/0)
Veronica's Lab 4 (4/0/0)
Alexis Kopinski 4 (3/1/0)
Lain 4 (2/1/1)
Uriel 4 (2/1/1)
Jessica's 7 (4/2/1)
Distribution Center 6 (4/1/1)
The Minute Clinic 5 (2/2/1)
Wanneng 4 (3/0/1)
AWAKEN 4 (2/0/2)
Xinjen Headquarters 3 (2/0/1)
The Node 3 (1/2/0)
Dragon's Den 2 (1/0/1)
So the most connected NPCs are Ms. Parker, Malachi, and Elizabeth, but the NPCs with the most connections to our Leads are Connor, Amanda, and Kurk.
The most connected locations are Jessica's, the Distribution Center, and the Minute Clinic, but if you look at most connections to leads, you keep Jessica's and the Distribution Center but swap in Veronica's Lab as #3.
Jessica's seems like the best place to start a scene for most of the Leads, and it looks like the NPCs who will be most involved in their lives will probably be Connor, Amanda and Kurk.
I always try to give NPCs some kind of identifiable personality traits, so if anyone has a strong feeling one way or the other about how I depict Connor, Amanda, Kurk, Elizabeth, Evelyn, Malachi, Jessica's, the Distribution Center, or the Minute Clinic, please let me know. Ideally, pass on anything you thought of when you created a character that you feel is important to who they are, otherwise i'll make it up and it might not be what you wanted.