@Carabas: we'd be starting with mortal characters and then as a group deciding where we want to go from there splat-wise. Staying as mortals would totally be an option too by the way.
I'll post the game later today and send invites to those who've expressed interest. We can discuss it further there.
Regarding plot, the basic opening premise will be investigating a missing persons case. The goals here being to get everyone comfortable with their characters and the system and setting up whatever is to follow. I'm a big fan of setting a few things up and just seeing where the players take it. You will have a lot of input with regard to where the story goes.