Gnome_Chomsky says:
BedzoneII, does the Mr. Nobody enhancement compensate for my aberrations, such as Sheer Hideousness? I don’t have any aberrations that make me overtly inhuman, but I was still wondering.
Let's treat Sheer Hideousness as the equivalent of Unearthly Beauty, which Mr Nobody can cover up.
Your Mega-Appearance is high enough for Mr Nobody to mask 5 Taint. This means your Taint and its accompanying aberrations will still peek through, but it's not as bad as when the Nobody mask drops. In fact, you'll have to use a quantum point constantly to keep up the Mr Nobody, otherwise everyone's gonna feel that 4 dot Mega-Ugliness and 8 Taint in a sanity-crushing way, all the time. (It's a bit like the problem Jomsviking's permanent QBolt suffers from).
Consider shifting some points into Dormancy? You'll need it to 'power down' the Mega-Ugliness so that you can have a regular life.
Btw, you should still get your 1 freebie dot in Appearance anyway at chargen, so go ahead and put that in.